Medical Entomology & Arthropod-transmitted Diseases

Contact Information:
Telephone: (701) 777 - 2199
FAX:  (701) 777 - 2623
email address: jefferson_vaughan@und.nodak.edu

Education:
1985 Ph.D. Entomology Virginia Polytechnic Institute & State University
1982 M.S. Entomology Virginia Polytechnic Institute & State University
1977 B.S. Biology Colorado State University

Post-doctoral & Associate Research Affilations:
University of Maryland School of Medicine
      1986-1989 Post-doctoral. Malaria & antibody passage in mosquitoes.
      1996-1999 Visiting Assistant Professor. Flea physiology, spotted fever rickettsiae, ticks.
Johns Hopkins School of Hygiene & Public Health
      1990-1993 Research Associate. Malaria sporogony.
      1995-1998 Research Associate. Microfilarial enhancement of arboviral transmission.
U.S. Army Medical Research Institute of Infectious Diseases
      1994-1998. Visiting Scientist. Parasitic enhancement of arboviral transmission.
      2001 - present. Visiting Scientist. Microfilarial enhancement of dengue transmission.

Research Interests:
Primary research interests center on the various insects and ticks that can transmit disease organisms to humans and wildlife.  Specific interests center on: 1) malaria parasite development within vector mosquitoes using a population dynamics approach, 2) potential of filarial infections to enhance arboviral infection of mosquitoes and 3) the effects that host blood components, such as antibody or drugs, can exert on both vector arthropods and the growth characteristics of pathogens developing within vector arthropods.

Graduate Students:

Christina M. Brewer - graduated with M.S. degree in Spring 2006. Thesis Title: "The potential for microfilarial enhancement of West Nile virus transmission in the Red River valley of North Dakota and Minnesota".

Shree Kanta S. Poudel - graduated with M.S. degree in Summer 2006. Thesis Title: "Rodent malaria: Population dynamics of early sporogonic development within the mosquito vector, Anopheles stephensi".

Gabriel Garman - M.S. student. Thesis Title: "Malaria: Quantitative analysis of sporozoite production and movement into mosquito salivary glands".

Jay Schroeder - M.S. student. Research Topic: Neorickettsia in Digenea.

S E L E C T E D    P U B L I C A T I O N S

----  Malaria  --- -

Zollner GE, N Ponsa, GW Garman, S Poudel, JA Bell, J Sattabongkot, RE Coleman and JA Vaughan . 2006. Population dynamics of sporogony for Plasmodium vivax parasites from western Thailand developing within three species of colonized Anopheles mosquitoes. Malaria J. 5: e68.

Vaughan, JA , Scheller, LF, RA Wirtz and AF Azad 1999. Comparative infectivity of Plasmodium berghei sporozoites to mice when delivered by intravenous inoculation versus infectious mosquito bite: implications for sporozoite vaccine trials. Inf. Immun. 67: 4285-4289.

Vaughan JA , BH Noden and JC Beier. 1994. Sporogonic development of cultured Plasmodium falciparum in six species of laboratory-reared Anopheles mosquitoes. Am. J. Trop. Med. Hyg. 51: 233-243.

Vaughan JA , BH Noden and JC Beier. 1992. Population dynamics of Plasmodium falciparum sporogony in laboratory-infected Anopheles gambiae . J. Parasitol. 78: 716-724.

----  Arboviruses ----

Bell JA, CM Brewer, NJ Mickelson, GW Garman and JA Vaughan . 2006. West Nile virus epizootiology, central Red River valley, North Dakota and Minnesota, 2002-2005. Emerg. Infect. Dis. 12: 1245-1247.

Vaughan, JA , M Trpis and MJ Turell 1999. Brugia malayi microfilariae enhance the infectivity of Venezuelan equine encephalitis virus to Aedes mosquitoes. J. Med. Entomol. 36:758-763.

Vaughan, JA and MJ Turell. 1996.  Dual host infections: enhanced infectivity of eastern equine encephalitis virus to Aedes mosquitoes mediated by Brugia microfilariae.  Am. J. Trop. Med. Hyg. 54: 105-109.

----  Fate of host blood components in bloodsucking arthropods  ----

Vaughan, JA , DE Sonenshine and AF Azad. 2002. Kinetics of ingested host immunoglobulin G in hemolymph and whole body homogenates during nymphal development of Dermacentor variabilis and Ixodes scapularis ticks (Acari: Ixodidae). Exp. Appl. Acarol. 27: 329-340.

Vaughan JA and AF Azad. 1993. Patterns of erythrocyte digestion by bloodsucking insects: constraints on vector competence. J. Med. Entomol. 30: 214-216.

Vaughan JA , BH Noden and JC Beier. 1991. Concentration of human erythrocytes by anopheline mosquitoes during feeding (Diptera: Culicidae). J. Med. Entomol. 28: 780-786.

Vaughan JA and AF Azad. 1988. Passage of host immunoglobulin G from bloodmeal into hemolymph of selected mosquito species. J. Med. Entomol. 25: 472-474.

C O M P L E T E    P U B L I C A T I O N    L I S T

1. Zollner GE, N Ponsa, GW Garman, S Poudel, JA Bell, J Sattabongkot, RE Coleman and JA Vaughan . 2006. Population dynamics of sporogony for Plasmodium vivax parasites from western Thailand developing within three species of colonized Anopheles mosquitoes. Malaria J. 5: e68.

2. Bell JA, CM Brewer, NJ Mickelson, GW Garman and JA Vaughan . 2006. West Nile virus epizootiology, central Red River valley, North Dakota and Minnesota, 2002-2005. Emerg. Infect. Dis. 12: 1245-1247.

3. Bell JA, NJ Mickelson, and JA Vaughan . 2005. West Nile virus in host-seeking mosquitoes within a residential neighborhood in Grand Forks, North Dakota. Vector-Borne and Zoonotic Dis. 5: 373-382.

4. Kuzmin Y, VV Tkach and JA Vaughan 2005 Rhadias kongmongthaensis sp. n. from Polypedates leucomystax (Amphibia, Anura, Rhacophoridae) in Thailand. Folia Parasitologica 52: 339-342.

5. Zollner GE, N Ponsa, RE Coleman, J Sattabongkot, and JA Vaughan . 2005. Efficacy of sampling techniques for determining absolute density of Plasmodium vivax ookinetes in Anopheles dirus mosquitoes. J. Parasitol. 91: 453-457.

6 . Vaughan, JA , DE Sonenshine and AF Azad. 2002. Kinetics of ingested host immunoglobulin G in hemolymph and whole body homogenates during nymphal development of Dermacentor variabilis and Ixodes scapularis ticks (Acari: Ixodidae). Exp. Appl. Acarol. 27: 329-340.

7. Lal, A, PS Patterson, JB Sacci, JA Vaughan , C Paul, WE Collins, RA Wirtz, and AF Azad 2001. Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship Proc. Nat. Acad. Sci. 98: 5228-5233.

8. Vaughan, JA. 2000. Which routes do Plasmodium sporozoites use for successful infections of vertebrates? (Letter to the Editor - Author's Reply). Infection and Immunity 68: 3064-3065.

9. Vaughan, JA , M Trpis and MJ Turell 1999. Brugia malayi microfilariae enhance the infectivity of Venezuelan equine encephalitis virus to Aedes mosquitoes. J. Med. Entomol. 36:758-763.

10. Vaughan, JA , Scheller, LF, RA Wirtz and AF Azad 1999. Comparative infectivity of Plasmodium berghei sporozoites to mice when delivered by intravenous inoculation versus infectious mosquito bite: implications for sporozoite vaccine trials. Inf. Immun. 67: 4285-4289.

11. Vaughan, JA , RE Thomas, GE Silver, N Wisznewski and AF Azad 1998. Quantitation of cat immunoglobulins in the hemolymph of cat fleas after bloodfeeding. J. Med. Entomol. 35(4): 404-409.

12. Vaughan, JA and MJ Turell. 1996. Facilitation of Rift Valley fever virus transmission by Plasmodium berghei sporozoites in Anopheles stephensi mosquitoes. Am. J. Trop. Med. Hyg. 55: 407-409.

13. Jaworski DC, JA Higgins, S. Radulovic, JA Vaughan , and AF Azad. 1996. Presence of calreticulin in vector fleas (Siphonaptera). J. Med. Entomol. 33: 482-489.

14. Vaughan, JA and MJ Turell. 1996. Dual host infections: enhanced infectivity of eastern equine encephalitis virus to Aedes mosquitoes mediated by Brugia microfilariae. Am. J. Trop. Med. Hyg. 54: 105-109.

15. Noden, BH, CB Pumpuni, JA Vaughan , and JC Beier. 1995. Noninfectious sporozoites in the salivary glands of a minimally susceptible anopheline mosquito. J. Parasitol. 81: 912-915.

16. Noden BH, JA Vaughan , MS Ibrahim and JC Beier. 1994. An immunological factor which affects Anopheles gambiae survival. J. Am. Mosquito Control Assoc. 11: 45-49.

17. Vaughan JA , L Henley and JC Beier. 1994. Sporogonic development of Plasmodium yoelii in five anopheline mosquitoes. J. Parasitol. 80: 674-681.

18. Noden BH, PS Beadle, JA Vaughan , CB Pumpuni, MD Kent and JC Beier. 1994. Plasmodium falciparum : the population structure of mature gametocyte cultures has little effect on their innate fertility. Acta Tropica 58: 13-19.

19. Vaughan JA , BH Noden and JC Beier. 1994. Prior blood feeding effects on susceptibility of Anopheles gambiae (Diptera: Culicidae) to infection with cultured Plasmodium falciparum (Haemosporida: Plasmodiidae). J. Med. Entomol. 31: 445-449.

20. Vaughan JA , BH Noden and JC Beier. 1994. Sporogonic development of cultured Plasmodium falciparum in six species of laboratory-reared Anopheles mosquitoes. Am. J. Trop. Med. Hyg. 51: 233-243.

21. Vaughan JA and AF Azad. 1993. Patterns of erythrocyte digestion by bloodsucking insects: constraints on vector competence. J. Med. Entomol. 30: 214-216.

22. Beier JC, MS Beier, JA Vaughan , CB Pumpuni, JR Davis and BH Noden. 1992. Sporozoite transmission by Anopheles freeborni and Anopheles gambiae experimentally infected with Plasmodium falciparum . J. Am. Mosquito Control Assoc. 8: 1-5.

23. Vaughan JA , BH Noden and JC Beier. 1992. Population dynamics of Plasmodium falciparum sporogony in laboratory-infected Anopheles gambiae . J. Parasitol. 78: 716-724.

24. Beier JC, JA Vaughan , A Madani and BH Noden. 1992. Plasmodium falciparum : release of circumsporozoite protein by sporozoites in the mosquito vector. Exp. Parasitol. 75: 248-256.

25. Beier JC, RS Copeland, R Mtalib and JA Vaughan . 1992. Ookinete rates in afrotropical anopheline mosquitoes as a measure of human malaria infectiousness. Am. J. Trop. Med. Hyg. 47: 41-46.

26. Vaughan JA , D Narum and AF Azad. 1991. Plasmodium berghei ookinete densities in three anopheline species. J. Parasitol. 77: 758-761.

27. Vaughan JA , BH Noden and JC Beier. 1991. Concentration of human erythrocytes by anopheline mosquitoes during feeding (Diptera: Culicidae). J. Med. Entomol. 28: 780-786.

28. Beier JC, JR Davis, JA Vaughan , BH Noden and MS Beier. 1991. Quantitation of Plasmodium falciparum sporozoites transmitted in vitro by experimentally-infected Anopheles gambiae and Anopheles stephensi . Am. J. Trop. Med. Hyg. 44: 564-570.

29. Vaughan JA and AF Azad. 1990. Acquisition of murine typhus rickettsiae by fleas. Ann. New York Acad. Sci. 590: 70-75.

30. Vaughan JA , RA Wirtz, VE do Rosario and AF Azad. 1989. Quantitation of anti-sporozoite immunoglobulins in the hemolymph of Anopheles stephensi after bloodfeeding. Am. J. Trop. Med. Hyg. 42: 10-16.

31. Vaughan JA , AE Jerse and AF Azad. 1989. Rat leucocyte response to the bites of the Oriental rat flea, Xenopsylla cheopis (Siphonaptera: Pulicidae). J. Med. Entomol. 26: 449-453.

32. Ribeiro JMC, JA Vaughan and AF Azad. 1989. Characterization of the salivary apyrases of three rodent flea species. Comp. Biochem. Physiol. 95: 215-218.

33. Vaughan JA and EC Turner Jr. 1989. Diurnal microdistribution of immature Culicoides variipennis (Coq.)(Diptera: Ceratopogonidae) at Saltville, VA, USA. J. Agric. Entomol. 6: 175-182.

34. Azad AF, JA Vaughan and RA Wirtz. 1989. Host anti-parasite IgG: Transport across the gut epithelial lining, and its influence on the infectivity of arthropod vectors. Proc. 2nd Symp. Host Regulated Developmental Mechanisms in Vector Arthropods. pp. 163-170.

35. Rosario VE, A Appiah, JA Vaughan and MR Hollingdale. 1989. Administration of anti-sporozoite antibodies during sporogony induce Plasmodium falciparum sporozoites no longer neutralized by human immune CS vaccine sera. Trans. Royal Soc. Trop. Med. Hyg. 83: 305-307.

36. Rosario VE, J Vaughan , M Murphy, V Harrod and R Coleman. 1989. Effect of chloroquine on the sporogonic cycle of Plasmodium falciparum and Plasmodium berghei in anopheline mosquitoes. Acta Leidensia 57: 53-60.

37. Coleman RE, JA Vaughan and VE do Rosario. 1989. Effect of mefloquine and qinghaosu on the sporogonic cycle of Plasmodium berghei ANKA in Anopheles stephensi mosquitoes. Acta Leidensia 57: 61-74.

38. Rosario VE, JA Vaughan and RE Coleman. 1989. A model for analysis of the sporogonic development of Plasmodium falciparum and Plasmodium berghei in anopheline mosquitoes. Parassitologia 1: 103-113.

39. Vaughan JA and AF Azad. 1988. Passage of host immunoglobulin G from bloodmeal into hemolymph of selected mosquito species. J. Med. Entomol. 25: 472-474.

40. Vaughan JA , V Rosario, P Leland, A Adjepong, J Light, G Woollett, MR Hollingdale and AF Azad. 1988. Plasmodium falciparum : Ingested anti-sporozoite antibodies affect sporogony in Anopheles stephensi mosquitoes. Exp. Parasitol. 66: 171-182.

41. Despins JL, JA Vaughan and EC Turner Jr. 1988. Interspecific and intraspecific predation in the lesser mealworm, Alphitobius diaperinus (Coleoptera: Tenebrionidae). Coleop. Bull. 42: 211-216.

42. Vaughan JA and EC Turner Jr. 1987. Seasonal microdistribution of immature Culicoides variipennis (Coq.)(Diptera: Ceratopogonidae) at Saltville, Virginia. J. Med. Entomol. 24: 340-346.

43. Vaughan JA and EC Turner Jr. 1987. Development of immature Culicoides variipennis (Coq.)(Diptera: Ceratopogonidae) from Saltville, Virginia, at constant laboratory temperatures. J. Med. Entomol. 24: 390-395.

44. Vaughan JA and EC Turner Jr. 1985. Spatial distribution of immature Culicoides variipennis (Coq.). Proc. Internat. Symp. on Bluetongue and Related Orbiviruses. Prog. Clin. Biol. Res. 178: 213-219.

45. Vaughan JA , EC Turner Jr. and PL Ruszler. 1984. Infestation and damage of poultry house insulation by the lesser mealworm, Alphitobius diaperinus (Panzer). Poultry Sci. 63: 1094-1110.

46. Vaughan JA and EC Turner Jr. 1984. Residual and topical toxicity of various insecticides to the lesser mealworm, Alphitobius diaperinus (Panzer)(Coleoptera: Tenebrionidae). J. Econ. Entomol. 77: 216-220.

47. Beck AF, JA Vaughan and EC Turner Jr. 1983. Bay Vi-7533 insect growth regulator: effect on house fly emergence and caged layer egg production when administered in layer feed. J. Georgia Entomol. Soc. 18: 159-163.